According to a team of pain researchers at Indiana University, adding a common epilepsy drug to a morphine regimen can result in better pain control with fewer side effects. Further, the combination can reduce the dosage of the opioid needed to be effective. In laboratory tests using rodents, researchers found that while morphine lost its pain-relieving effectiveness three weeks after nerve injury, a combination therapy of morphine and carbamazepine—used to prevent epileptic seizures—could effectively reverse this loss of drug action. Their findings were reported in the journal PLOS ONE. The discovery could be especially useful for neuropathic pain, which is systemic and particularly difficult to treat, while reducing the likelihood of dependence on the opioid component by keeping the dosage low from the very beginning of treatment.
Read the full overview from Workers’ Comp Insitute 360 here.